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Symbiotic streptomycetes provide antibiotic combination prophylaxis for wasp offspring

Kroiss, Johannes ; Kaltenpoth, Martin ; Schneider, Bernd ; Schwinger, Maria-Gabriele ; Hertweck, Christian ; Maddula, Ravi Kumar ; Strohm, Erhard ; Svatoš, Aleš



Abstract

Beewolf digger wasps cultivate specific symbiotic bacteria (Streptomyces spp.) that are incorporated into the larval cocoon for protection against pathogens. We identified the molecular basis of this protective symbiosis in the natural context and demonstrate that the bacteria produce a 'cocktail' of nine antibiotic substances. The complementary action of all symbiont-produced antibiotics confers ...

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