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A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2with serum creatinine level

Pattaro, Cristian ; De Grandi, Alessandro ; Vitart, Veronique ; Hayward, Caroline ; Franke, Andre ; Aulchenko, Yurii S ; Johansson, Asa ; Wild, Sarah H ; Melville, Scott A ; Isaacs, Aaron ; Polasek, Ozren ; Ellinghaus, David ; Kolcic, Ivana ; Nöthlings, Ute ; Zgaga, Lina ; Zemunik, Tatijana ; Gnewuch, Carsten ; Schreiber, Stefan ; Campbell, Susan ; Hastie, Nick ; Boban, Mladen ; Meitinger, Thomas ; Oostra, Ben A ; Riegler, Peter ; Minelli, Cosetta ; Wright, Alan F ; Campbell, Harry ; van Duijn, Cornelia M ; Gyllensten, Ulf ; Wilson, James F ; Krawczak, Michael ; Rudan, Igor ; Pramstaller, Peter P



Abstract

Background: Serum creatinine (S-CR) is the most important biomarker for a quick and non-invasive assessment of kidney function in population-based surveys. A substantial proportion of the inter-individual variability in SCR level is explicable by genetic factors. Methods: We performed a meta-analysis of genome-wide association studies of SCR undertaken in five population isolates ('discovery ...

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