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Task2 potassium channels set central respiratory CO 2 and O 2 sensitivity

Gestreau, Christian ; Heitzmann, Dirk ; Thomas, Joerg ; Dubreuil, Véronique ; Bandulik, Sascha ; Reichold, Markus ; Bendahhou, Saïd ; Pierson, Patricia ; Sterner, Christina ; Peyronnet-Roux, Julie ; Benfriha, Chérif ; Tegtmeier, Ines ; Ehnes, Hannah ; Georgieff, Michael ; Lesage, Florian ; Brunet, Jean-Francois ; Goridis, Christo ; Warth, Richard ; Barhanin, Jacques



Abstract

Task2 K+ channel expression in the central nervous system is surprisingly restricted to a few brainstem nuclei, including the retrotrapezoid (RTN) region. All Task2-positive RTN neurons were lost in mice bearing a Phox2b mutation that causes the human congenital central hypoventilation syndrome. In plethysmography, Task2(-/-) mice showed disturbed chemosensory function with hypersensitivity to ...

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