| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Hormone Research in Paediatrics | ||||
| Publisher: | KARGER | ||||
| Place of Publication: | BASEL | ||||
| Volume: | 73 | ||||
| Number of Issue or Book Chapter: | 3 | ||||
| Page Range: | pp. 175-180 | ||||
| Date: | 2010 | ||||
| Institutions: | Medicine > Lehrstuhl für Strahlentherapie | ||||
| Identification Number: |
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| Keywords: | GROWTH-HORMONE TREATMENT; BODY-MASS INDEX; QUALITY-OF-LIFE; BRAIN-TUMORS; SURVIVORS; THERAPY; RISK; REPLACEMENT; RECURRENCE; OUTCOMES; Childhood craniopharyngioma; Growth hormone; Recurrence; Survival; Hypothalamus | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 66565 |
Web of ScienceAbstract
Background: Controversies surround various treatment variables for patients with childhood craniopharyngioma such as growth hormone (GH) replacement, which some believe can exacerbate recurrence/progression. We prospectively assessed the risk of tumor recurrence/progression in survivors of childhood craniopharyngioma. Methods: Multivariable analyses of risk factors (age at diagnosis, degree of ...
Abstract
Background: Controversies surround various treatment variables for patients with childhood craniopharyngioma such as growth hormone (GH) replacement, which some believe can exacerbate recurrence/progression. We prospectively assessed the risk of tumor recurrence/progression in survivors of childhood craniopharyngioma. Methods: Multivariable analyses of risk factors (age at diagnosis, degree of resection, irradiation, GH treatment and gender) and descriptive analyses of overall survival (OS) and event-free survival (EFS) rates were performed in 117 patients, recruited prospectively and evaluated after 3 years of follow-up in the German, Austrian and Swiss multicenter trial KRANIOPHARYNGEOM 2000. Results: We observed a 3-year OS of 0.97 and a 3-year EFS of 0.46, indicating high recurrence rates after complete resection (CR) (n = 47; 3-year-EFS: 0.64) and high progression rates after incomplete resection (IR) (n = 64; 3-year EFS: 0.31). The risk of an event decreased by 80% after CR compared to IR (hazard ratio = 0.20; p < 0.001). Irradiation had protective effects on EFS: irradiated patients had an 88% lower risk of recurrence/progression compared to patients without/before irradiation (hazard ratio = 0.12; p < 0.001). GH treatment had no impact on 3-year EFS rates. Conclusions: Tumor recurrences/progressions are frequent and occur early after initial treatment of childhood craniopharyngioma. A radical resection preserving the integrity of hypothalamic structures appears optimal at original diagnosis. Irradiation was efficient in preventing recurrences/progressions. GH treatment had no impact on the low 3-year EFS observed in our study. However, further conclusions on the influence of GH on recurrence rates have to be refined to long-term follow-up studies of patients with childhood craniopharyngioma. Copyright (C) 2010 S. Karger AG, Basel
Metadata last modified: 19 Dec 2024 11:47
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