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A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

Soranzo, Nicole ; Spector, Tim D. ; Mangino, Massimo ; Kühnel, Brigitte ; Rendon, Augusto ; Teumer, Alexander ; Willenborg, Christina ; Wright, Benjamin ; Chen, Li ; Li, Mingyao ; Salo, Perttu ; Voight, Benjamin F. ; Burns, Philippa ; Laskowski, Roman A. ; Xue, Yali ; Menzel, Stephan ; Altshuler, David ; Bradley, John R. ; Bumpstead, Suzannah ; Burnett, Mary-Susan ; Devaney, Joseph ; Döring, Angela ; Elosua, Roberto ; Epstein, Stephen E. ; Erber, Wendy ; Falchi, Mario ; Garner, Stephen F. ; Ghori, Mohammed J. R. ; Goodall, Alison H. ; Gwilliam, Rhian ; Hakonarson, Hakon H. ; Hall, Alistair S. ; Hammond, Naomi ; Hengstenberg, Christian ; Illig, Thomas ; König, Inke R. ; Knouff, Christopher W. ; McPherson, Ruth ; Melander, Olle ; Mooser, Vincent ; Nauck, Matthias ; Nieminen, Markku S. ; O'Donnell, Christopher J. ; Peltonen, Leena ; Potter, Simon C. ; Prokisch, Holger ; Rader, Daniel J. ; Rice, Catherine M. ; Roberts, Robert ; Salomaa, Veikko ; Sambrook, Jennifer ; Schreiber, Stefan ; Schunkert, Heribert ; Schwartz, Stephen M. ; Serbanovic-Canic, Jovana ; Sinisalo, Juha ; Siscovick, David S. ; Stark, Klaus ; Surakka, Ida ; Stephens, Jonathan ; Thompson, John R. ; Völker, Uwe ; Völzke, Henry ; Watkins, Nicholas A. ; Wells, George A. ; Wichmann, H.-Erich ; Van Heel, David A. ; Tyler-Smith, Chris ; Thein, Swee Lay ; Kathiresan, Sekar ; Perola, Markus ; Reilly, Muredach P. ; Stewart, Alexandre F. R. ; Erdmann, Jeanette ; Samani, Nilesh J. ; Meisinger, Christa ; Greinacher, Andreas ; Deloukas, Panos ; Ouwehand, Willem H. ; Gieger, Christian



Abstract

The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci ...

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