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In situ analysis of the antigen-processing machinery in acute myeloid leukaemic blasts by tissue microarray

Hoves, S ; Aigner, M ; Pfeiffer, C ; Laumer, M ; Obermann, E C ; Mackensen, A



Zusammenfassung

Altered expression of major histocompatibility complex (MHC) class I molecules can be caused by defects in genes of the antigen-processing machinery (APM), and is often correlated to progression in solid tumours. However, little is known about expression of the APM components in blasts from patients with acute myeloid leukaemia (AML). In this study, we investigated the expression of the APM ...

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