Machnik, Agnes ; Neuhofer, Wolfgang ; Jantsch, Jonathan ; Dahlmann, Anke ; Tammela, Tuomas ; Machura, Katharina ; Park, Joon-Keun ; Beck, Franz-Xaver ; Müller, Dominik N ; Derer, Wolfgang ; Goss, Jennifer ; Ziomber, Agata ; Dietsch, Peter ; Wagner, Hubertus ; van Rooijen, Nico ; Kurtz, Armin ; Hilgers, Karl F ; Alitalo, Kari 
; Eckardt, Kai-Uwe ; Luft, Friedrich C ; Kerjaschki, Dontscho ; Titze, Jens
; Eckardt, Kai-Uwe ; Luft, Friedrich C ; Kerjaschki, Dontscho ; Titze, Jens 
Abstract
In salt-sensitive hypertension, the accumulation of Na(+) in tissue has been presumed to be accompanied by a commensurate retention of water to maintain the isotonicity of body fluids. We show here that a high-salt diet (HSD) in rats leads to interstitial hypertonic Na(+) accumulation in skin, resulting in increased density and hyperplasia of the lymphcapillary network. The mechanisms underlying ...
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