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Preventive usage of broad spectrum chemokine inhibitor NR58-3.14.3 reduces the severity of pulmonary and hepatic graft-versus-host disease

Miklos, Sandra ; Mueller, Gunnar ; Chang, Yayi ; Bouazzaoui, Abdellatif ; Spacenko, Elena ; Schubert, Thomas E. O. ; Grainger, David J. ; Holler, Ernst ; Andreesen, Reinhard ; Hildebrandt, Gerhard C.



Zusammenfassung

Pulmonary graft-versus-host disease (pGVHD) is a major complication after allogeneic bone marrow transplantation (BMT), which involves donor leukocyte migration into the lung along chemokine gradients, leading to pulmonary dysfunction and respiratory insufficiency. As broad spectrum chemokine inhibitor (BSCI) NR58-3.14.3 suppresses leukocyte migration in response to various chemokines, including ...

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