| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Klinische Monatsblätter für Augenheilkunde | ||||
| Publisher: | GEORG THIEME VERLAG KG | ||||
| Place of Publication: | STUTTGART | ||||
| Volume: | 226 | ||||
| Number of Issue or Book Chapter: | 01 | ||||
| Page Range: | pp. 60-65 | ||||
| Date: | 2009 | ||||
| Institutions: | Medicine > Lehrstuhl für Augenheilkunde | ||||
| Identification Number: |
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| Keywords: | SUBFOVEAL CHOROIDAL NEOVASCULARIZATION; COMBINED PHOTODYNAMIC THERAPY; MACULAR DEGENERATION; VERTEPORFIN THERAPY; CLINICAL-TRIAL; PROLIFERATIVE VITREORETINOPATHY; ADJUNCTIVE TREATMENT; ACETONIDE; INJECTION; BEVACIZUMAB; retina; age-related macular degeneration; photodynamic therapy; Triamcinolone; intravitreal injection; randomised study | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 67594 |
Web of ScienceAbstract
Background: Combination therapy of photodynamic therapy (PDT) with intravitreal triamcinolone (IVTA) for choroidal neovascularisation (CNV) in age-related macular degeneration is thought to improve the prognosis. It is therefore widely used, although results are mostly based upon non-randomised and retrospective studies. Here we present the 6-month results of our prospective, randomised, ...
Abstract
Background: Combination therapy of photodynamic therapy (PDT) with intravitreal triamcinolone (IVTA) for choroidal neovascularisation (CNV) in age-related macular degeneration is thought to improve the prognosis. It is therefore widely used, although results are mostly based upon non-randomised and retrospective studies. Here we present the 6-month results of our prospective, randomised, multicentre ITAP trial (Intravitreal Triamcinolone and PDT) for the evaluation of the combination therapy as compared to PDT alone. Patients: This prospective, randomised, multicentre phase III trial was performed for the evaluation of the efficacy and safety of combination therapy (PDT and IVTA) as compared to PDT alone. Three randomised therapy groups (A: PDT alone, B: IVTA on the same day I hour after PDT C: IVTA I week before PDT) were monitored over I year. The patients included had wet AMD with predominantly classic CNV, minimal classic CNV smaller than 4 papillary diameters or occult CNV with recent disease progression. Re-treatment was performed when persistent leakage of the CNV was visible at follow-up. Primary outcome criteria were the comparison between combination therapy and PDT monotherapy concerning visual acuity, and, second, the comparison between the two groups of combination therapy. Results: 92 patients were included in the study. Before treatment, mean best corrected ETDRS letter score was 52, 53 and 51 in groups A, B and C, respectively. At the 6 months follow-up, mean best corrected letter score was 40, 47 and 47, respectively, with only group A loosing more than 10 letters. This change, however, was not statistically significant between the groups. Mean retinal thickness as measured with optical coherence tomography decreased in all groups, and reached statistical significance in both combination groups. Re-treatment rates did not differ significantly between the three groups at 6 months follow-up, nor was there a significant cataract progression requiring operation. Conclusion: At 6 months there was no significant difference between mono- and combination therapy groups concerning visual acuity.
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