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Activation of Wnt signalling in stroma from pancreatic cancer identified by gene expression profiling

Pilarsky, Christian ; Ammerpohl, Ole ; Sipos, Bence ; Dahl, Edgar ; Hartmann, Arndt ; Wellmann, Axel ; Braunschweig, Till ; Löhr, Matthias ; Jesnowski, Ralf ; Friess, Helmut ; Wente, Moritz Nicolas ; Kristiansen, Glen ; Jahnke, Beatrix ; Denz, Axel ; Rückert, Felix ; Schackert, Hans K. ; Klöppel, Günter ; Kalthoff, Holger ; Saeger, Hans Detlev ; Grützmann, Robert



Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant desmoplastic stroma. Interactions between cancer and stromal cells play a critical role in tumour invasion, metastasis and chemoresistance. Therefore, we hypothesized that gene expression profile of the stromal components of pancreatic carcinoma is different from chronic pancreatitis and reflects the interaction with the ...

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