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A cell-based approach to the minimization of immunosuppression in renal transplantation

Hutchinson, James A. ; Brem-Exner, Beate G. ; Riquelme, Paloma ; Roelen, Dave ; Schulze, Maren ; Ivens, Katrin ; Grabensee, Bernd ; Witzke, Oliver ; Philipp, Thomas ; Renders, Lutz ; Humpe, Andreas ; Sotnikova, Anna ; Matthi, Martina ; Heumann, Asmus ; Gvert, Felix ; Schulte, Thilo ; Kabelitz, Dieter ; Claas, Frans H. J. ; Geissler, Edward K. ; Kunzendorf, Ulrich ; Fndrich, Fred



Abstract

Five renal transplant recipients were preoperatively treated with transplant acceptance-inducing cells (TAICs) in a Phase-I safety study of TAICs as an adjunct immune-conditioning therapy in living-donor kidney transplantation. Initially, patients received anti-thymocyte globulin induction therapy in combination with tacrolimus and steroid immunosuppression. Over the course of 12 weeks, steroids ...

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