| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | European Radiology | ||||
| Publisher: | SPRINGER | ||||
| Place of Publication: | NEW YORK | ||||
| Volume: | 18 | ||||
| Number of Issue or Book Chapter: | 3 | ||||
| Page Range: | pp. 457-467 | ||||
| Date: | 2008 | ||||
| Institutions: | Medicine > Lehrstuhl für Röntgendiagnostik | ||||
| Identification Number: |
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| Keywords: | GD-EOB-DTPA; PHASE HELICAL CT; SUPERPARAMAGNETIC IRON-OXIDE; ARTERIAL PORTOGRAPHY; HEPATIC METASTASES; HEPATOCELLULAR-CARCINOMA; GADOBENATE DIMEGLUMINE; COLORECTAL-CANCER; CONTRAST AGENTS; ULTRASONOGRAPHY; magnetic resonance imaging; computed tomography; focal liver lesions; liver-specific; hepatobiliary; gadoxetic acid-enhanced MRI; therapeutic strategy | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 68320 |
Web of ScienceAbstract
A multicenter study has been employed to evaluate the diagnostic efficacy of magnetic resonance imaging (MRI) using the new liver-specific contrast agent gadoxetic acid (Gd-EOB-DTPA, Primovist), as opposed to contrast-enhanced biphasic spiral computed tomography (CT), in the diagnosis of focal liver lesions, compared with a standard of reference (SOR). One hundred and sixty-nine patients with ...
Abstract
A multicenter study has been employed to evaluate the diagnostic efficacy of magnetic resonance imaging (MRI) using the new liver-specific contrast agent gadoxetic acid (Gd-EOB-DTPA, Primovist), as opposed to contrast-enhanced biphasic spiral computed tomography (CT), in the diagnosis of focal liver lesions, compared with a standard of reference (SOR). One hundred and sixty-nine patients with hepatic lesions eligible for surgery underwent Gd-EOB-DTPA-enhanced MRI as well as CT within 6 weeks. Pathologic evaluation of the liver specimen combined with intraoperative ultrasound established the SOR. Data sets were evaluated on-site (14 investigators) and off-site (three independent blinded readers). Gd-EOB-DTPA was well tolerated. Three hundred and two lesions were detected in 131 patients valid for analysis by SOR. The frequency of correctly detected lesions was significantly higher on Gd-EOB-DTPA-enhanced MRI compared with CT in the clinical evaluation [10.44%; 95% confidence interval (CI): 4.88, 16.0]. In the blinded reading there was a trend towards Gd-EOB-DTPA-enhanced MRI, not reaching statistical significance (2.14%; 95% CI: -4.32, 8.6). However, the highest rate of correctly detected lesions with a diameter below 1 cm was achieved by Gd-EOB-DTPA-enhanced MRI. Differential diagnosis was superior for Gd-EOB-DTPA-enhanced MRI (82.1%) versus CT (71.0%). A change in surgical therapy was documented in 19 of 131 patients (14.5%) post Gd-EOB-DTPA-enhanced MRI. Gd-EOB-DTPA-enhanced MRI was superior in the diagnosis and therapeutic management of focal liver lesions compared with CT.
Metadata last modified: 19 Dec 2024 13:23
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