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Aerosol immunization with NYVAC and MVA vectored vaccines is safe, simple, and immunogenic

Corbett, Max ; Bogers, Willy M. ; Heeney, Jonathan L. ; Gerber, Stefan ; Genin, Christian ; Didierlaurent, Arnaud ; Oostermeijer, Herman ; Dubbes, Rob ; Braskamp, Gerco ; Lerondel, Stéphanie ; Gomez, Carmen E. ; Esteban, Mariano ; Wagner, Ralf ; Kondova, Ivanella ; Mooij, Petra ; Balla-Jhagjhoorsingh, Sunita ; Beenhakker, Niels ; Koopman, Gerrit ; van der Burg, Sjoerd ; Kraehenbuhl, Jean-Pierre ; Le Pape, Alain



Abstract

Each year, approximately five million people die worldwide from putatively vaccine-preventable mucosally transmitted diseases. With respect to mass vaccination campaigns, one strategy to cope with this formidable challenge is aerosol vaccine delivery, which offers potential safety, logistical, and cost-saving advantages over traditional vaccination routes. Additionally, aerosol vaccination may ...

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