Abstract
Aim: In the present study we have investigated the potential of autogenous osteoblasts for osteoinduction in a spinal arthrodesis model. Method: After posterolateral instrumentation of 3 segments of a sheep spine the intervertebral space was filled with cancellous bone, osteoblasts OF left empty after nucleotomy and elimination of cartilage. Results: Radiological and histological analyses proved ...
Abstract
Aim: In the present study we have investigated the potential of autogenous osteoblasts for osteoinduction in a spinal arthrodesis model. Method: After posterolateral instrumentation of 3 segments of a sheep spine the intervertebral space was filled with cancellous bone, osteoblasts OF left empty after nucleotomy and elimination of cartilage. Results: Radiological and histological analyses proved a significant osseous reaction in segments treated with cancellous bone or osteoblasts in contrast to the control segment. This outcome provides evidence of spondylodeses by spinal instrumentation in combination with osteoblasts in a sheep model. Conclusion: The results suggest a possible application of autologous osteoblasts as an osteoinductor after percutaneous nucleotomy in spinal fusion. The possible application in a human model should be examined.
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