Zusammenfassung
Objective. The chemokine receptor CCR2 is highly expressed on monocytes and considered a promising target for treatment of rheumatoid arthritis. However, blockade of CCR2 with a monoclonal antibody (mAb) during progression of collagen -induced arthritis results in a massive aggravation of the disease. In this study we investigated why CCR2 antibodies have proin-flammatory effects, how these ...
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