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Rybp, a polycomb complex-associated protein, is required for mouse eye development

Pirity, Melinda K. ; Wang, Wei-Lin ; Wolf, Louise V. ; Tamm, Ernst R. ; Schreiber-Agus, Nicole ; Cvekl, Ales



Zusammenfassung

Background: Rybp (Ring1 and YY1 binding protein) is a zinc finger protein which interacts with the members of the mammalian polycomb complexes. Previously we have shown that Rybp is critical for early embryogenesis and that haploinsufficiency of Rybp in a subset of embryos causes failure of neural tube closure. Here we investigated the requirement for Rybp in ocular development using four in vivo ...

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