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Analysis of vascular gene expression in arthritic synovium by laser‐mediated microdissection

Hashimoto, Atsushi ; Tarner, Ingo H. ; Bohle, Rainer M. ; Gaumann, Andreas ; Manetti, Mirko ; Distler, Oliver ; Steinmeyer, Jürgen ; Ulfgren, Ann‐Kristin ; Schulz, Andreas ; Gay, Steffen ; Müller‐Ladner, Ulf ; Neumann, Elena



Zusammenfassung

Objective. In rheumatoid arthritis (RA), formation of new blood vessels is necessary to meet the nutritional and oxygen requirements of actively proliferating synovial tissue. The aim of this study was to analyze the specific synovial vascular expression profiles of several angiogenesis-related genes as well as CD82 in RA compared with osteoarthritis (OA), using laser-mediated microdissection ...

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