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Hyperhomocysteinemia and Myocardial Expression of Brain Natriuretic Peptide in Rats

Herrmann, Wolfgang ; Böhm, Michael ; Hans Straub, Rainer ; Umanskaya, Natalia ; Kilter, Heiko ; Pexa, Anette ; Hübner, Ulrich ; Taban-Shoma, Omid ; Herrmann, Markus



Zusammenfassung

Background: Hyperhomocysteinemia (HHcy) has been linked to impaired left ventricular function and clinical class in patients with chronic heart failure. We hypothesized that HHcy stimulates myocardial brain natriuretic peptide (BNP) expression and induces adverse left ventricular remodeling. Methods: We randomized 50 rats into 5 groups. Groups Col and Co2 (controls) received a typical diet. ...

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