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Spontaneous CD8 T Cell Responses against the Melanocyte Differentiation Antigen RAB38/NY-MEL-1 in Melanoma Patients

Walton, Senta M. ; Gerlinger, Marco ; de la Rosa, Olga ; Nuber, Natko ; Knights, Ashley ; Gati, Asma ; Laumer, Monika ; Strauss, Laura ; Exner, Carolin ; Schäfer, Niklaus ; Urosevic, Mirjana ; Dummer, Reinhard ; Tiercy, Jean-Marie ; Mackensen, Andreas ; Jaeger, Elke ; Lévy, Frédéric ; Knuth, Alexander ; Jäger, Dirk ; Zippelius, Alfred



Abstract

The melanocyte differentiation Ag RAB38/NY-MEL-1 was identified by serological expression cloning (SEREX) and is expressed in the vast majority of melanoma lesions. The immunogenicity of RAB38/NY-MEL-1 has been corroborated previously by the frequent occurrence of specific Ab responses in melanoma patients. To elucidate potential CD8 T cell responses, we applied in vitro sensitization with ...

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