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Immunohistochemical localization of apolipoprotein A-IV in human kidney tissue

Haiman, Marina ; Salvenmoser, Willi ; Scheiber, Karl ; Lingenhel, Arno ; Rudolph, Christian ; Schmitz, Gerd ; Kronenberg, Florian ; Dieplinger, Hans



Abstract

Background. Apolipoprotein A-IV (ApoA-IV) is a 46 kD glycoprotein thought to protect against atherosclerosis. It is synthesized primarily in epithelial cells of the small intestine. Elevated plasma concentrations of ApoA-IV in patients with chronic kidney disease suggest that the human kidney is involved in ApoA-IV metabolism. Methods. To investigate whether the human kidney directly metabolizes ...

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