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Characterization of the human zinc finger protein 267 promoter: Essential role of nuclear factor Y

Hu, Kanghong ; Fink, Marina ; Froh, Matthias ; Gäbele, Erwin ; Hellerbrand, Claus ; Mühlbauer, Marcus ; Wiest, Reiner ; Schölmerich, Jürgen ; Schnabl, Bernd



Zusammenfassung

Liver fibrosis results from an excessive deposition of extracellular matrix proteins secreted by activated hepatic stellate cells (HSCs). The activation process is accompanied by an increased activity of various transcription factors, including zinc finger protein 267 (ZNF267). Recently, ZNF267 has been shown to modulate gene expression and to function as a transcriptional repressor. MMP-10 was ...

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