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Dose-escalated treosulphan in combination with cyclophosphamide as a new preparative regimen for allogeneic haematopoietic stem cell transplantation in patients with an increased risk for regimen-related complications

Beelen, D. W. ; Trenschel, R. ; Casper, J. ; Freund, M. ; Hilger, R. A. ; Scheulen, M. E. ; Basara, N. ; Fauser, A. A. ; Hertenstein, B. ; Mylius, H. A. ; Baumgart, J. ; Pichlmeier, U. ; Hahn, J. R. ; Holler, E.



Zusammenfassung

Treosulphan has recently demonstrated antileukaemic activity and potent haematopoietic stem cell toxicity. Dose-escalated treosulphan ( 3 x 12 or 3 x 14 g/m(2)) combined with cyclophosphamide (Cy) was chosen for a new preparative regimen before allogeneic haematopoietic stem cell transplantation in 18 patients ( median age 44, range 19 - 64 years) with haematological malignancies, considered ...

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