Superiority of voriconazole over amphotericin B in the treatment of invasive aspergillosis after heart transplantation

Abstract

Invasive aspergillosis in immuncompromised patients occurs frequently. Surgical therapy in combination with chemotherapy with amphotericin B and itraconazole is standard therapy. We describe a heart transplant recipient with invasive Aspergillus fumigatus infection in the lung, which was treated successfully with voriconazole after systemically high-dose intravenous therapy with amphotericin B failed. Copyright (C) 2005 by the International Society for Heart and Lung Transplantation.