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The Microarray Expression Analysis Identifies BAX as a Mediator of β-Carotene Effects on Apoptosis

Bodzioch, Marek ; Dembinska-Kiec, Aldona ; Hartwich, Jadwiga ; Lapicka-Bodzioch, Katarzyna ; Banas, Agnieszka ; Polus, Anna ; Grzybowska, Joanna ; Wybranska, Iwona ; Dulinska, Joanna ; Gil, Dorota ; Laidler, Piotr ; Placha, Wojciech ; Zawada, Magdalena ; Balana-Nowak, Agnieszka ; Sacha, Tomasz ; Kiec-Wilk, Beata ; Skotnicki, Aleksander ; Moehle, Christoph ; Langmann, Thomas ; Schmitz, Gerd



Abstract

beta-Carotene is a ubiquitous compound rich in foods. However, there are conflicting reports regarding its role in carcinogenesis. We performed a microarray expression analysis in normal [human umbilical vein endothelial cells (HUVECs)] and neoplastic (melanoma A375 and myelomonocytic leukemia U937) actively proliferating cells and found evidence that beta-carotene stimulated vital cellular ...

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