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The effect of anti-L-selectin (aselizumab) in multiple traumatized patients—Results of a phase II clinical trial*

Seekamp, Andreas ; van Griensven, Martijn ; Dhondt, Erwin ; Diefenbeck, Michael ; Demeyer, Ignace ; Vundelinckx, Guy ; Haas, Norbert ; Schaechinger, Ulrich ; Wolowicka, Laura ; Rammelt, Stefan ; Stroobants, Jan ; Marzi, Ingo ; Brambrink, Ansgar M. ; Dziurdzik, Piotr ; Gasiorowski, Jacek ; Redl, Heinz ; Beckert, Michael ; Khan-Boluki, Jasmin



Abstract

Objective: The objectives of this study were to evaluate safety (primary) and clinical efficacy (secondary) of the humanized monoclonal anti-L-selectin antibody aselizumab in severely injured patients. Design: Prospective phase II, parallel group, double-blind, randomized, placebo-controlled clinical trial. Setting: Fourteen medical intensive care units or trauma units in level I trauma centers ...

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