Abstract
Lissencephalies are a. clinically and genetically heterogeneous group of cerebral malformations characterized by the lack of cortical organization due to impaired neuronal migration during embryogenesis. Lissencephalies are divided into isolated forms and syndromic forms that are associated with additional cerebral malformations and multi-organ dysfunction. Clinically, epileptic seizures as well ...
Abstract
Lissencephalies are a. clinically and genetically heterogeneous group of cerebral malformations characterized by the lack of cortical organization due to impaired neuronal migration during embryogenesis. Lissencephalies are divided into isolated forms and syndromic forms that are associated with additional cerebral malformations and multi-organ dysfunction. Clinically, epileptic seizures as well as mental retardation are present in affected patients. Several genes were recently identified to be causally linked to different forms of isolated lissencephalies and systematic mutational analysis may reveal new lissencephally associated genes.
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