Abstract
Background: This investigation prospectively evaluated the effect of oral premedication of two different doses of ketamine with midazolam and midazolam alone on the recovery of children after sevoflurane anaesthesia. Methods: In a randomized, double-blind study, 79 children (aged 1-8 years, ASA physical status I or II) were assigned to receive one of three premedications in a volume of 0.5 ...
Abstract
Background: This investigation prospectively evaluated the effect of oral premedication of two different doses of ketamine with midazolam and midazolam alone on the recovery of children after sevoflurane anaesthesia. Methods: In a randomized, double-blind study, 79 children (aged 1-8 years, ASA physical status I or II) were assigned to receive one of three premedications in a volume of 0.5 ml.kg(-1) : group 1 received midazolam 0.5 mg.kg(-1) (MD); group 2 received midazolam 0.5 mg.kg(-1) with ketamine 1.8 mg.kg(-1) (MK-1); and group 3 received midazolam 0.5 mg.kg(-1) with ketamine 3 mg.kg(-1) (MK-2). The reactions of the children during administration were noted. Anaesthesia was induced by facemask with incremental sevoflurane administration. All children received alfentanil (15 mug.kg(-1)). Tracheal intubation was facilitated by mivacurium (0.2 mg.kg(-1)). Anaesthesia was maintained with sevoflurane and an additional dose of alfentanil, if necessary. During recovery, the time interval between discontinuation of anaesthesia and arousal (spontaneous ventilation, extubation) were recorded. Results: Emergence (spontaneous ventilation, extubation) and recovery times (discharge, Aldrete score = 9) did not differ significantly between groups (P = 0.24, P = 0.59 and P = 0.145, respectively). Conclusions : The combination of midazolam and ketamine as oral preanaesthetic medication did not significantly affect the recovery time of children after sevoflurane anaesthesia.
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