Abstract
Bivalent Lewis X (Le(x)) oligosaccharides were synthesised in order to study the conformational details of carbohydrate clusters by NMR spectroscopy. To this end, two Le(x) trisaccharide moieties (1) were covalently linked through the 6-hydroxy group or through the anomeric oxygen of GlcNAc to yield dimers 2 and 3, respectively. The two Le(x) halves of the model saccharide 2 exhibited ...
Abstract
Bivalent Lewis X (Le(x)) oligosaccharides were synthesised in order to study the conformational details of carbohydrate clusters by NMR spectroscopy. To this end, two Le(x) trisaccharide moieties (1) were covalently linked through the 6-hydroxy group or through the anomeric oxygen of GlcNAc to yield dimers 2 and 3, respectively. The two Le(x) halves of the model saccharide 2 exhibited cooperativity in calcium binding. Three different lactosides served as control compounds for NMR titration with calcium chloride.
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