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EFFECTS OF SELECTIVE iNOS INHIBITION ON GUT AND LIVER O2-EXCHANGE AND ENERGY METABOLISM DURING HYPERDYNAMIC PORCINE ENDOTOXEMIA

Matějovič, Martin ; Radermacher, Peter ; Tugtekin, Ilyas ; Stehr, Alexander ; Theisen, Marc ; Vogt, Josef ; Wachter, Ulrich ; Ploner, Franz ; Georgieff, Michael ; Träger, Karl



Abstract

We have previously demonstrated that non-selective nitric oxide synthase (NOS) inhibition did not reverse the LPS-induced deterioration of hepato-splanchnic energy status in porcine endotoxic shock. Therefore, this study investigated the effect of selective inducible NOS (iNOS) inhibition using 1400W on intestinal and liver perfusion, O-2 kinetics, and energy metabolism during hyperdynamic ...

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