OXTR-mediated signaling in astrocytes contributes to anxiolysis

URN to cite this document:: urn:nbn:de:bvb:355-epub-745427
DOI to cite this document:: 10.5283/epub.74542

Meinung, Carl-Philipp

; Boi, Laura

; Pandamooz, Sareh

; Mazaud, David ; Ghézali, Grégory ; Rouach, Nathalie ; Neumann, Inga D.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 07 Jan 2025 08:59

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Abstract

Astrocytes are an indispensable part of signal processing within the mammalian brain. Thus, the mode of action of a neuropeptide such as oxytocin (OXT) can only be fully understood considering this integral part of the CNS. Here, we show that OXT regulates astrocytic gene expression, intracellular signaling and specific proteins both in vitro and in vivo. This translates into rapid regulation of ...