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Holzapfel, Dominik Emanuel ; Kappenschneider, Tobias ; Schuster, Marie Farina ; Pagano, Stefano ; Azar, Fady ; Holzapfel, Sabrina ; Meyer, Matthias

Influence of parkinson’s disease on complications and revisions in total hip and knee arthroplasty: insights from a matched pair analysis

Holzapfel, Dominik Emanuel , Kappenschneider, Tobias, Schuster, Marie Farina, Pagano, Stefano, Azar, Fady, Holzapfel, Sabrina and Meyer, Matthias (2025) Influence of parkinson’s disease on complications and revisions in total hip and knee arthroplasty: insights from a matched pair analysis. International Orthopaedics.

Date of publication of this fulltext: 30 Jan 2025 06:55
Article
DOI to cite this document: 10.5283/epub.74764


Abstract

Purpose The outcome of elective total joint arthroplasty (TJA) in patients with Parkinson’s disease (PD) is controversial due to the concomitant risk profile. This study investigated postoperative complications and revision rates following total hip (THA) and knee arthroplasty (TKA) in patients with PD. Methods Ninety-six patients with PD undergoing THA or TKA were matched 1:1 with non-PD ...

Purpose
The outcome of elective total joint arthroplasty (TJA) in patients with Parkinson’s disease (PD) is controversial due to the concomitant risk profile. This study investigated postoperative complications and revision rates following total hip (THA) and knee arthroplasty (TKA) in patients with PD.
Methods
Ninety-six patients with PD undergoing THA or TKA were matched 1:1 with non-PD patients using propensity score matching for age, sex and comorbidity (Charlson Comorbidity index, CCI). Rates of revisions, medical and surgical complications were compared. Univariate and multivariate regression analyses were calculated.
Results
PD patients exhibited higher rates of revision-surgeries within 90 days (13.5% vs. 5.2%; p = 0.048), medical complications (68.8% vs. 43.8%; p < 0.001) and surgical complications (40.6% vs. 21.9%; p = 0.005). Multivariate regression analysis confirmed PD as a significant risk factor for complications and long-term revision-surgeries.
Conclusion
PD increases the risk of adverse outcomes following THA and TKA. Improvements in pre-operative planning and post-operative care are critical to the improvement of outcomes in this vulnerable population.



Involved Institutions


Details

Item typeArticle
Journal or Publication TitleInternational Orthopaedics
Publisher:Springer
Open Access Type:DEAL (Springer)
Date24 January 2025
InstitutionsMedicine > Lehrstuhl für Kinder- und Jugendmedizin
Medicine > Lehrstuhl für Orthopädie
Identification Number
ValueType
10.1007/s00264-024-06398-9DOI
KeywordsParkinson’s disease · TJA · TKA · THA · Postoperative complications · Revision surgery
Dewey Decimal Classification600 Technology > 610 Medical sciences Medicine
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgPartially
URN of the UB Regensburgurn:nbn:de:bvb:355-epub-747641
Item ID74764

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