Laryngectomy plus postoperative radio(system)therapy versus primary radio(system) therapy for the treatment of locally advanced laryngeal and hypopharyngeal cancer – results from the University Clinical Cancer Registry Regensburg

URN to cite this document:

urn:nbn:de:bvb:355-epub-748672 Copy

DOI to cite this document:

10.5283/epub.74867 Copy

Maurer, Julia ; Kuenzel, Julian ; Bohr, Christopher ; Koelbl, Oliver ; Mueller, Karolina ; Koller, Michael ; Concato, Oreste-Konrad ; Vielsmeier, Veronika ; Suess, Christoph

Date of publication of this fulltext: 05 Feb 2025 13:29

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Alternative links to fulltext:DOIPublisher

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Details

Item type:	Article
Open Access Type:	No Open Access
Journal or Publication Title:	Acta Oto-Laryngologica
Publisher:	Taylor and Francis
Volume:	144
Number of Issue or Book Chapter:	3
Page Range:	pp. 255-262
Date:	25 April 2024
Institutions:	UNSPECIFIED
Identification Number:	Value Type 10.1080/00016489.2024.2340086 DOI
Keywords:	Hypopharygeal/laryngeal cancer, laryngectomy, primary radio(system)therapy, overall survival, recommended therapy
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	74867

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Abstract

Background There are few adequate randomized clinical trials directly comparing the therapeutic options of primary laryngectomy (pLE) vs. primary radio(system)therapy (pR(S)T) in patients with locally advanced laryngeal and hypopharyngeal carcinoma and thus little clear scientific evidence to decide which patients will benefit most from which procedure. Aims/Objectives Aim was to compare ...

Abstract

Background

There are few adequate randomized clinical trials directly comparing the therapeutic options of primary laryngectomy (pLE) vs. primary radio(system)therapy (pR(S)T) in patients with locally advanced laryngeal and hypopharyngeal carcinoma and thus little clear scientific evidence to decide which patients will benefit most from which procedure.
Aims/Objectives

Aim was to compare survival between the therapeutic options and to learn from the limitations of this study, especially in the context of improved clinical assessment.
Material and Methods

The clinical data of patients treated between January 2010 and February 2022 were obtained from the electronic database of the University Hospital Regensburg. Overall survival (OS) and progression-free survival (PFS) were compared between the treatment groups.
Results

The study included 193 patients (pLE n = 68, pR(S)T, n = 125). Median OS was 31.2 months and median PFS was 24.7 months with no significant difference between the treatment groups (p > .050). Patients who did not receive complete treatment as recommended by the tumor conference (n = 47, 24.4%) had a higher risk of death (p = .024).
Conclusions and Significance

The results of our study are consistent with the survival data reported in the literature. More detailed systematic data in clinical routine (e.g. relevant comorbidities) are required to ensure guideline-based recommended therapy.

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Metadata last modified: 28 May 2025 17:06

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