Virus-reactive T cells expanded in aplastic anemia eliminate hematopoietic progenitor cells by molecular mimicry

URN to cite this document:: urn:nbn:de:bvb:355-epub-748694
DOI to cite this document:: 10.5283/epub.74869

Ben Hamza, Amin ; Welters, Carlotta ; Stadler, Serena ; Brüggemann, Monika ; Dietze, Kerstin ; Brauns, Olaf ; Brümmendorf, Tim H. ; Winkler, Thomas W.

; Bullinger, Lars ; Blankenstein, Thomas ; Rosenberger, Leonie ; Leisegang, Matthias ; Kammertöns, Thomas ; Herr, Wolfgang ; Moosmann, Andreas ; Strobel, Julian ; Hackstein, Holger ; Dornmair, Klaus ; Beier, Fabian ; Hansmann, Leo

Date of publication of this fulltext: 05 Feb 2025 13:56

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Abstract

Acquired aplastic anemia is a bone marrow failure syndrome characterized by hypocellular bone marrow and peripheral blood pancytopenia. Frequent clinical responses to calcineurin inhibition and antithymocyte globulin strongly suggest critical roles for hematopoietic stem/progenitor cell–reactive T-cell clones in disease pathophysiology; however, their exact contribution and antigen specificities ...