Comparative electrochemical study of oxidative nicarbazin determination in non-aqueous media: Differential pulse voltammetry vs. capillary electrophoresis with amperometric detection

URN to cite this document:

urn:nbn:de:bvb:355-epub-750390 Copy

DOI to cite this document:

10.5283/epub.75039 Copy

Ivakh, Sofiia ; Koall, Martin ; Barek, Jiří ; Matysik, Frank-Michael

License: Creative Commons Attribution 4.0 PDF - Published Version (3MB)

Date of publication of this fulltext: 26 Feb 2025 05:36

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Details

Item type:	Article
Open Access Type:	DEAL (Elsevier)
Journal or Publication Title:	Talanta
Publisher:	Elsevier
Volume:	288
Page Range:	p. 127729
Date:	11 February 2025
Institutions:	Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Instrumentelle Analytik (Prof. Frank-Michael Matysik)
Identification Number:	Value Type 10.1016/j.talanta.2025.127729 DOI
Keywords:	Electrochemistry, Complementary study, Capillary electrophoresis, Differential pulse voltammetry, Electrochemical detection, Quality control, Mass spectrometry
Dewey Decimal Classification:	500 Science > 540 Chemistry & allied sciences
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Partially
Item ID:	75039

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Abstract

Background Electrochemistry offers a range of powerful techniques for solving analytical problems, each with its own advantages and limitations that can significantly affect the information obtained. These variations lead to diverse requirements for newly developed methods. Applying multiple electrochemical techniques simultaneously can optimize information extraction from a sample, aiding in ...

Abstract

Background
Electrochemistry offers a range of powerful techniques for solving analytical problems, each with its own advantages and limitations that can significantly affect the information obtained. These variations lead to diverse requirements for newly developed methods. Applying multiple electrochemical techniques simultaneously can optimize information extraction from a sample, aiding in the selection of the best analytical approach.
Results
In this study, we present the first investigation of the oxidation of the coccidiostat nicarbazin, along with a comparative evaluation of two established electrochemical methods with complementary strengths: differential pulse voltammetry (DPV) and capillary electrophoresis coupled with amperometric detection (CE-AD). We thoroughly examine the oxidative determination of nicarbazin in poultry feed samples using acetonitrile based media. DPV allows for rapid and efficient analysis, while CE-AD excels in handling complex samples with electrochemically active species due to its high separation efficiency. Both methods exhibit limits of detection (LODs) in the low micromolar range. To provide a comprehensive understanding of the nicarbazin oxidation process, the final reaction products were analyzed by mass spectrometry, identifying 4-nitroaniline and (4-nitrophenyl)formamide as key product compounds.
Significance and novelty
This pioneering research on the anodic detection of nicarbazin includes a detailed analysis of the components in the studied equimolar mixture. The developed protocols, combined with straightforward sample preparation, enable the successful determination of nicarbazin levels below those allowed by EU regulations.

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Metadata last modified: 02 Jun 2025 08:01

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