Fatty Acid Synthase Promotes Hepatocellular Carcinoma Growth via S-Phase Kinase-Associated Protein 2/p27KIP1 Regulation

URN to cite this document:: urn:nbn:de:bvb:355-epub-750873
DOI to cite this document:: 10.5283/epub.75087

Cigliano, Antonio

; Simile, Maria M. ; Vidili, Gianpaolo ; Pes, Giovanni M. ; Dore, Maria P. ; Urigo, Francesco ; Cossu, Eleonora ; Che, Li ; Feo, Claudio ; Steinmann, Sara M.

; Ribback, Silvia ; Pascale, Rosa M. ; Evert, Matthias ; Chen, Xin ; Calvisi, Diego F.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 04 Mar 2025 08:49

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Abstract

Background and Objectives: Aberrant upregulation of fatty acid synthase (FASN), catalyzing de novo synthesis of fatty acids, occurs in various tumor types, including human hepatocellular carcinoma (HCC). Although FASN oncogenic activity seems to reside in its pro-lipogenic function, cumulating evidence suggests that FASN’s tumor-supporting role might also be metabolic-independent. Materials ...