Lamprey Parapinopsin (“UVLamP”): a Bistable UV‐Sensitive Optogenetic Switch for Ultrafast Control of GPCR Pathways

URN to cite this document:: urn:nbn:de:bvb:355-epub-751505
DOI to cite this document:: 10.5283/epub.75150

Eickelbeck, Dennis

; Rudack, Till

; Tennigkeit, Stefan Alexander

; Surdin, Tatjana ; Karapinar, Raziye ; Schwitalla, Jan‐Claudius ; Mücher, Brix ; Shulman, Maiia ; Scherlo, Marvin ; Althoff, Philipp ; Mark, Melanie D.

; Gerwert, Klaus

; Herlitze, Stefan

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
PDF - Published Version
(1MB)

Date of publication of this fulltext: 20 Mar 2025 06:33

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

Optogenetics uses light-sensitive proteins, so-called optogenetic tools, for highly precise spatiotemporal control of cellular states and signals. The major limitations of such tools include the overlap of excitation spectra, phototoxicity, and lack of sensitivity. The protein characterized in this study, the Japanese lamprey parapinopsin, which we named UVLamP, is a promising optogenetic tool to ...