The Ras dimer structure

URN to cite this document:: urn:nbn:de:bvb:355-epub-751557
DOI to cite this document:: 10.5283/epub.75155

Rudack, Till

; Teuber, Christian ; Scherlo, Marvin ; Güldenhaupt, Jörn ; Schartner, Jonas ; Lübben, Mathias

; Klare, Johann P.

; Gerwert, Klaus

; Kötting, Carsten

License: Creative Commons: Attribution-Noncommercial 3.0
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Date of publication of this fulltext: 20 Mar 2025 07:25

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Abstract

Oncogenic mutated Ras is a key player in cancer, but despite intense and expensive approaches its catalytic center seems undruggable. The Ras dimer interface is a possible alternative drug target. Dimerization at the membrane affects cell growth signal transduction. In vivo studies indicate that preventing dimerization of oncogenic mutated Ras inhibits uncontrolled cell growth. Conventional ...