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Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing

du Halgouet, Anastasia ; Darbois, Aurélie ; Alkobtawi, Mansour ; Mestdagh, Martin ; Alphonse, Aurélia ; Premel, Virginie ; Yvorra, Thomas ; Colombeau, Ludovic ; Rodriguez, Raphaël ; Zaiss, Dietmar ; El Morr, Yara ; Bugaut, Hélène ; Legoux, François ; Perrin, Laetitia ; Aractingi, Selim ; Golub, Rachel ; Lantz, Olivier ; Salou, Marion



Abstract

Tissue repair processes maintain proper organ function following mechanical or infection-related damage. In addition to antibacterial properties, mucosal associated invariant T (MAIT) cells express a tissue repair transcriptomic program and promote skin wound healing when expanded. Herein, we use a human-like mouse model of full-thickness skin excision to assess the underlying mechanisms of MAIT ...

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