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Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via lipocalin-2

Adler, Omer ; Zait, Yael ; Cohen, Noam ; Blazquez, Raquel ; Doron, Hila ; Monteran, Lea ; Scharff, Yeela ; Shami, Tamar ; Mundhe, Dhanashree ; Glehr, Gunther ; Kanner, Andrew A. ; Horn, Suzana ; Yahalom, Vered ; Haferkamp, Sebastian ; Hutchinson, James A. ; Bleckmann, Annalen ; Nahary, Limor ; Benhar, Itai ; Yust Katz, Shlomit ; Pukrop, Tobias ; Erez, Neta



Abstract

Adler et al. identify granulocyte-derived lipocalin-2 as a mediator of inflammatory astrocyte activation, which in turn facilitates brain metastasis in breast cancer and melanoma. Brain metastasis still encompass very grim prognosis and therefore understanding the underlying mechanisms is an urgent need toward developing better therapeutic strategies. We uncover the intricate interactions between ...

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