Online error rate control for platform trials

URN to cite this document:: urn:nbn:de:bvb:355-epub-758623
DOI to cite this document:: 10.5283/epub.75862

Robertson, David S. ; Wason, James M. S.

; König, Franz ; Posch, Martin

; Jaki, Thomas

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 18 Mar 2025 10:06

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Abstract

Platform trials evaluate multiple experimental treatments under a single master protocol, where new treatment arms are added to the trial over time. Given the multiple treatment comparisons, there is the potential for inflation of the overall type I error rate, which is complicated by the fact that the hypotheses are tested at different times and are not necessarily pre-specified. Online error ...