Abstract
BackgroundCongenital cytomegalovirus (cCMV) infection can cause severe neurological damage, growth retardation, hearing loss, and microcephaly in infants. We aimed at assessing healthcare costs of infants with recorded cCMV diagnosis in an administrative claims database in the first 2 years of life.MethodsWe conducted a retrospective, controlled cohort study using German claims data from the ...
Abstract
BackgroundCongenital cytomegalovirus (cCMV) infection can cause severe neurological damage, growth retardation, hearing loss, and microcephaly in infants. We aimed at assessing healthcare costs of infants with recorded cCMV diagnosis in an administrative claims database in the first 2 years of life.MethodsWe conducted a retrospective, controlled cohort study using German claims data from the Institute for Applied Health Research Berlin (InGef) database. Incremental healthcare costs during the first and second year of life were assessed by matching (1:60) infants with cCMV diagnoses <= 90 days after birth (cCMV(90) cohort) to infants without cCMV diagnosis ("representative" controls) and infants with cCMV diagnoses <= 21 days after birth plus specific symptoms (cCMV(21-S)) to infants without cCMV and any ICD-10-GM records (besides Z00-Z99) until 4(th) preventive health check-up ("healthy" controls). Due to missing data, mean imputation was applied for aids and remedies costs.ResultsWe identified 54 and 24 infants born 2014-2018 for the cCMV(90) and cCMV(21-S) cohorts, respectively. During the first year, mean (median) healthcare costs were significantly higher in cCMV(90) cases vs. "representative" controls (euro22,737 (euro9759) vs. euro3091 (euro863), p < 0.001), with 87.2% inpatient costs. Healthcare costs for cCMV(21-S) cases compared to "healthy" controls were euro34,498 (euro20,924) vs. euro680 (euro569), p < 0.001. Differences decreased for both comparisons in the second year but remained statistically significant.ConclusionscCMV comprises a considerable economic burden for the German healthcare system (euro19,646 to euro33,818 higher mean costs for infants with recorded cCMV diagnosis in the first year of life). Attempts should be made to reduce this burden.
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