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Systematic comparison of HIV-1 Envelope-specific IgG responses induced by different vaccination regimens: Can we steer IgG recognition towards regions of viral vulnerability?

Horvath, Augusta ; Rogers, Lisa ; Pollakis, Georgios ; Baranov, Olga ; Pieroth, Nora ; Joseph, Sarah ; Chachage, Mkunde ; Heitzer, Asli ; Maganga, Lucas ; Msafiri, Frank ; Joachim, Agricola ; Viegas, Edna ; Eller, Leigh-Anne ; Kibuuka, Hannah ; Rerks-Ngarm, Supachai ; Pitisuttithum, Punnee ; Nitayapan, Sorachai ; Dhitavat, Jittima ; Premsri, Nakorn ; Fidler, Sarah ; Shattock, Robin J. ; Robb, Merlin Lee ; Weber, Jonathan ; McCormack, Sheena ; Munseri, Patricia Jane ; Lyamuya, Eligius ; Nilsson, Charlotta ; Kroidl, Arne ; Hoelscher, Michael ; Wagner, Ralf ; Geldmacher, Christof ; Held, Kathrin



Abstract

Immunogens and vaccination regimens can influence patterns of immune-epitope recognition, steering them towards or away from epitopes of potential viral vulnerability. HIV-1 envelope (Env)-specific antibodies targeting variable region 2 (V2) or 3 (V3) correlated with protection during the RV144 trial, however, it was suggested that the immunodominant V3 region might divert antibody responses away ...

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