Steiner, Ivana ; Flores-Tellez, Teresita del N.J. 
; Mevel, Renaud ; Ali, Amin ; Wang, Pengbo ; Schofield, Pieta ; Behan, Caron ; Forsythe, Nicholas ; Ashton, Garry ; Taylor, Catherine ; Mills, Ian G. ; Oliveira, Pedro ; McDade, Simon S. ; Zaiss, Dietmar M. ; Choudhury, Ananya ; Lacaud, Georges ; Baena, Esther
; Mevel, Renaud ; Ali, Amin ; Wang, Pengbo ; Schofield, Pieta ; Behan, Caron ; Forsythe, Nicholas ; Ashton, Garry ; Taylor, Catherine ; Mills, Ian G. ; Oliveira, Pedro ; McDade, Simon S. ; Zaiss, Dietmar M. ; Choudhury, Ananya ; Lacaud, Georges ; Baena, Esther 
Abstract
The emergence of castration-resistant prostate cancer remains an area of unmet clinical need. We recently identified a subpopulation of normal prostate progenitor cells, characterized by an intrinsic resistance to androgen deprivation and expression of LY6D. We here demonstrate that conditional deletion of PTEN in the murine prostate epithelium causes an expansion of transformed LY6D+ progenitor ...
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