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Rapid recruitment and IFN-I–mediated activation of monocytes dictate focal radiotherapy efficacy

Tadepalli, Sirimuvva ; Clements, Derek R. ; Saravanan, Sanjana ; Arroyo Hornero, Rebeca ; Lüdtke, Anja ; Blackmore, Beau ; Paulo, Joao A. ; Gottfried-Blackmore, Andres ; Seong, David ; Park, Soyoon ; Chan, Leslie ; Kopecky, Benjamin J. ; Liu, Zhaoyuan ; Ginhoux, Florent ; Lavine, Kory J. ; Murphy, John Patrick ; Mack, Matthias ; Graves, Edward E. ; Idoyaga, Juliana



Abstract

The recruitment of monocytes and their differentiation into immunosuppressive cells is associated with the low efficacy of preclinical nonconformal radiotherapy (RT) for tumors. However, nonconformal RT (non-CRT) does not mimic clinical practice, and little is known about the role of monocytes after RT modes used in patients, such as conformal RT (CRT). Here, we investigated the acute immune ...

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