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Effect of postoperative systemic prednisolone on short-term and long-term outcomes in chronic rhinosinusitis with nasal polyps: A multi-centered randomized clinical trial

Mueller, Sarina K. ; Wendler, Olaf ; Mayr, Susanne ; Traxdorf, Maximilian ; Hosemann, Werner ; Olze, Heidi ; Steinhart, Helmut ; Wiegand, Susanne ; Teymoortash, Afshin ; Kuehnel, Thomas ; Hackenberg, Stephan ; Hummel, Thomas ; Ambrosch, Petra ; Fazel, Azita ; Schick, Bernhard ; Baenkler, Hanns-Wolf ; Koch, Michael ; Buerner, Harald ; Mantsopoulos, Konstantinos ; Grundtner, Philipp ; Nocera, Angela ; Agaimy, Abbas ; Bleier, Benjamin ; Iro, Heinrich



Abstract

IntroductionThe objective of this study was to determine whether postoperative additive systemic steroid administration in chronic rhinosinusitis with nasal polyps (CRSwNP) impacted selected endoscopic, subjective and objective outcome measures. MethodsThis was a prospective, randomized, double-blind, placebo-controlled, noninferiority multicenter trial of n=106 patients with CRSwNP. All patients ...

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