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Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain

Szczepańska, Katarzyna ; Karcz, Tadeusz ; Dichiara, Maria ; Mogilski, Szczepan ; Kalinowska-Tłuścik, Justyna ; Pilarski, Bogusław ; Leniak, Arkadiusz ; Pietruś, Wojciech ; Podlewska, Sabina ; Popiołek-Barczyk, Katarzyna ; Humphrys, Laura J. ; Ruiz-Cantero, M. Carmen ; Reiner-Link, David ; Leitzbach, Luisa ; Łażewska, Dorota ; Pockes, Steffen ; Górka, Michał ; Zmysłowski, Adam ; Calmels, Thierry ; Cobos, Enrique J. ; Marrazzo, Agostino ; Stark, Holger ; Bojarski, Andrzej J. ; Amata, Emanuele ; Kieć-Kononowicz, Katarzyna



Abstract

In search of new dual-acting histamine H-3/sigma-1receptorligands, we designed a series of compounds structurally based on highlyactive in vivo ligands previously studied and describedby our team. However, we kept in mind that within the previous series,a pair of closely related compounds, KSK67 and KSK68, differing only in the piperazine/piperidine moietyin the structural core showed a ...

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