Risk factors for a severe disease course in children with SARS-COV-2 infection following hematopoietic cell transplantation in the pre-Omicron period: a prospective multinational Infectious Disease Working Party from the European Society for Blood and Marrow Transplantation group (EBMT) and the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH) study

Averbuch, Dina ; de la Camara, Rafael ; Tridello, Gloria ; Knelange, Nina Simone ; Bykova, Tatiana A. ; Ifversen, Marianne ; Dobsinska, Veronika ; Ayas, Mouhab ; Hamidieh, Amir Ali ; Pichler, Herbert ; Perez-Martinez, Antonio ; Cesaro, Simone ; Sundin, Mikael ; Badell, Isabel ; Bader, Peter ; Johansson, Jan-Erik ; Mirci-Danicar, Oana ; Sedlacek, Petr ; Paillard, Catherine ; Gibson, Brenda ; Lawson, Sarah ; Kroeger, Nicolaus ; Corbacioglu, Selim ; Mikulska, Malgorzata ; Piñana, Jose Luis ; Styczynski, Jan ; Ljungman, Per

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Alternative Links zum Volltext:DOIVerlag

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Details

Dokumentenart:	Artikel
Titel eines Journals oder einer Zeitschrift:	Bone Marrow Transplantation
Verlag:	SPRINGERNATURE
Ort der Veröffentlichung:	LONDON
Band:	58
Nummer des Zeitschriftenheftes oder des Kapitels:	5
Seitenbereich:	S. 558-566
Datum:	2023
Institutionen:	Medizin > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation
Identifikationsnummer:	Wert Typ 10.1038/s41409-023-01941-5 DOI
Stichwörter / Keywords:	OUTCOMES; RECIPIENTS; COVID-19; STATES;
Dewey-Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
Status:	Veröffentlicht
Begutachtet:	Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:	Ja
Dokumenten-ID:	76281

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Zusammenfassung

Risk factors for severe SARS-Cov-2 infection course are poorly described in children following hematopoietic cell transplantation (HCT). In this international study, we analyzed factors associated with a severe course (intensive care unit (ICU) admission and/or mortality) in post-HCT children. Eighty-nine children (58% male; median age 9 years (min-max 1-18)) who received an allogeneic (85; 96%) ...

Zusammenfassung

Risk factors for severe SARS-Cov-2 infection course are poorly described in children following hematopoietic cell transplantation (HCT). In this international study, we analyzed factors associated with a severe course (intensive care unit (ICU) admission and/or mortality) in post-HCT children. Eighty-nine children (58% male; median age 9 years (min-max 1-18)) who received an allogeneic (85; 96%) or an autologous (4; 4%) HCT were reported from 28 centers (18 countries). Median time from HCT to SARS-Cov-2 infection was 7 months (min-max 0-181). The most common clinical manifestations included fever (37; 42%) and cough (26; 29%); 37 (42%) were asymptomatic. Nine (10%) children following allo-HCT required ICU care. Seven children (8%) following allo-HCT, died at a median of 22 days after SARS-Cov-2 diagnosis. In a univariate analysis, the probability of a severe disease course was higher in allo-HCT children with chronic GVHD, non-malignant disease, immune suppressive treatment (specifically, mycophenolate), moderate immunodeficiency score, low Lansky score, fever, cough, coinfection, pulmonary radiological findings, and high C-reactive protein. In conclusion, SARS-Cov-2 infection in children following HCT was frequently asymptomatic. Despite this, 10% needed ICU admission and 8% died in our cohort. Certain HCT, underlying disease, and SARS-Cov-2 related factors were associated with a severe disease course.

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