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Phase 2 study of natalizumab plus standard corticosteroid treatment for high-risk acute graft-versus-host disease

Al Malki, Monzr M. ; London, Kaitlyn ; Baez, Janna ; Akahoshi, Yu ; Hogan, William J. ; Etra, Aaron ; Choe, Hannah ; Hexner, Elizabeth ; Langston, Amelia ; Abhyankar, Sunil ; Ponce, Doris M. ; DeFilipp, Zachariah ; Kitko, Carrie L. ; Adekola, Kehinde ; Reshef, Ran ; Ayuk, Francis ; Capellini, Alexandra ; Chanswangphuwana, Chantiya ; Eder, Matthias ; Eng, Gilbert ; Gandhi, Isha ; Grupp, Stephan ; Gleich, Sigrun ; Holler, Ernst ; Javorniczky, Nora Rebeka ; Kasikis, Stelios ; Kowalyk, Steven ; Morales, George ; Özbek, Umut ; Rösler, Wolf ; Spyrou, Nikolaos ; Yanik, Gregory ; Young, Rachel ; Chen, Yi-Bin ; Nakamura, Ryotaro ; Ferrara, James L. M. ; Levine, John E.



Abstract

Graft-versus-host disease (GVHD) of the gastrointestinal (GI) tract is the main cause of nonrelapse mortality (NRM) after allogeneic hematopoietic cell transplantation. Ann Arbor (AA) scores derived from serum biomarkers at onset of GVHD quantify GI crypt damage; AA2/3 scores correlate with resistance to treatment and higher NRM. We conducted a multicenter, phase 2 study using natalizumab, a ...

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