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Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance

Calvisi, Diego F. ; Boulter, Luke ; Vaquero, Javier ; Saborowski, Anna ; Fabris, Luca ; Rodrigues, Pedro M. ; Coulouarn, Cédric ; Castro, Rui E. ; Segatto, Oreste ; Raggi, Chiara ; van der Laan, Luc J. W. ; Carpino, Guido ; Goeppert, Benjamin ; Roessler, Stephanie ; Kendall, Timothy J. ; Evert, Matthias ; Gonzalez-Sanchez, Ester ; Valle, Juan W. ; Vogel, Arndt ; Bridgewater, John ; Borad, Mitesh J. ; Gores, Gregory J. ; Roberts, Lewis R. ; Marin, Jose J. G. ; Andersen, Jesper B. ; Alvaro, Domenico ; Forner, Alejandro ; Banales, Jesus M. ; Cardinale, Vincenzo ; Macias, Rocio I. R. ; Vicent, Silve ; Chen, Xin ; Braconi, Chiara ; Verstegen, Monique M. A. ; Fouassier, Laura ; Roberts, Lewis ; Scheiter, Alexander ; Selaru, Florin M. ; Evert, Katja ; Utpatel, Kirsten ; Broutier, Laura ; Cadamuro, Massimiliano ; Huch, Meritxell ; Goldin, Robert ; Gradilone, Sergio A. ; Saito, Yoshimasa



Abstract

Preclinical research is required to improve our understanding of cholangiocarcinoma (CCA). In this Consensus Statement, a task force of experts provides recommendations on the criteria for preclinical models of CCA to increase disease understanding and help to develop novel therapeutic approaches. Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary tree. CCA ...

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