Skin Cancer Induction by the Antimycotic Drug Voriconazole Is Caused by Impaired DNA Damage Detection Due to Chromatin Compaction

URN to cite this document:: urn:nbn:de:bvb:355-epub-764191
DOI to cite this document:: 10.5283/epub.76419

Giovannini, Sara ; Weibel, Lisa ; Schittek, Birgit ; Sinnberg, Tobias ; Schaller, Martin ; Lemberg, Christina ; Fehrenbacher, Birgit ; Biesemeier, Antje ; Nordin, Renate ; Ivanova, Irina

; Kurz, Bernadett ; Svilenska, Teodora ; Berger, Christoph ; Bourquin, Jean-Pierre

; Kulik, Andreas ; Fassihi, Hiva ; Lehmann, Alan ; Sarkany, Robert ; Kobert, Nikita ; van Toorn, Marvin ; Marteijn, Jurgen A. ; French, Lars E. ; Rocken, Martin ; Vermeulen, Wim ; Kamenisch, York ; Berneburg, Mark

Date of publication of this fulltext: 19 Mar 2025 15:29

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Abstract

Phototoxicity and skin cancer are severe adverse effects of the anti-fungal drug voriconazole (VOR). These adverse effects resemble those seen in xeroderma pigmentosum, caused by defective DNA nucleotide excision repair (NER), and we show that VOR decreases NER capacity. We show that VOR treatment does not perturb the expression of NER, or other DNA damage-related genes, but that VOR localizes to ...